Detail publikace

Magnetically Driven Self-Degrading Zinc-Containing Cystine Microrobots for Treatment of Prostate Cancer

USSIA, M. URSO, M. KRATOCHVÍLOVÁ, M. NAVRÁTIL, J. BALVAN, J. MAYORGA-MARTINEZ, C. VYSKOČIL, J. MASAŘÍK, M. PUMERA, M.

Originální název

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Prostate cancer is the most commonly diagnosed tumor disease in men, and its treatment is still a big challenge in standard oncology therapy. Magnetically actuated microrobots represent the most promising technology in modern nanomedicine, offering the advantage of wireless guidance, effective cell penetration, and non-invasive actuation. Here, new biodegradable magnetically actuated zinc/cystine-based microrobots for in situ treatment of prostate cancer cells are reported. The microrobots are fabricated via metal-ion-mediated self-assembly of the amino acid cystine encapsulating superparamagnetic Fe3O4 nanoparticles (NPs) during the synthesis, which allows their precise manipulation by a rotating magnetic field. Inside the cells, the typical enzymatic reducing environment favors the disassembly of the aminoacidic chemical structure due to the cleavage of cystine disulfide bonds and disruption of non-covalent interactions with the metal ions, as demonstrated by in vitro experiments with reduced nicotinamide adenine dinucleotide (NADH). In this way, the cystine microrobots served for site-specific delivery of Zn2+ ions responsible for tumor cell killing via a "Trojan horse effect". This work presents a new concept of cell internalization exploiting robotic systems' self-degradation, proposing a step forward in non-invasive cancer therapy.

Klíčová slova

cysteine; magnetic actuation; micromotors; nanorobots; self-propulsion; tumors

Autoři

USSIA, M.; URSO, M.; KRATOCHVÍLOVÁ, M.; NAVRÁTIL, J.; BALVAN, J.; MAYORGA-MARTINEZ, C.; VYSKOČIL, J.; MASAŘÍK, M.; PUMERA, M.

Vydáno

1. 4. 2023

Nakladatel

WILEY-V C H VERLAG GMBH

Místo

WEINHEIM

ISSN

1613-6829

Periodikum

Small

Ročník

Číslo

Stát

Spolková republika Německo

Strany počet

URL

https://onlinelibrary.wiley.com/doi/10.1002/smll.202208259

Plný text v Digitální knihovně

http://hdl.handle.net/11012/213673

BibTex

@article{BUT183952,
  author="Martina {Ussia} and Mario {Urso} and Monika {Kratochvílová} and Jiří {Navrátil} and Jan {Balvan} and Carmen C. {Mayorga-Martinez} and Jan {Vyskočil} and Michal {Masařík} and Martin {Pumera}",
  title="Magnetically Driven Self-Degrading Zinc-Containing Cystine Microrobots for Treatment of Prostate Cancer",
  journal="Small",
  year="2023",
  volume="19",
  number="17",
  pages="12",
  doi="10.1002/smll.202208259",
  issn="1613-6829",
  url="https://onlinelibrary.wiley.com/doi/10.1002/smll.202208259"
}

Odpovědnost: Ing. Marek Strakoš